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學經歷： | ||||||||||||||||||||||||||||||
| 經歷： 國立台北科技大學 化學工程與生物科技系所 教授 2009- 國立台北科技大學 化學工程與生物科技系所 副教授 2006-2009 國立台北科技大學 校友聯絡中心基金發展組 組長 2006-2008 國立台北科技大學 化學工程與生物科技系所 助理教授 2003-2006 美國商業部國家標準技術研究院 (NIST) 客座研究員 1996-2003 學歷： 美國馬里蘭大學(U. of Maryland at College Park) 化學工程學 博士 2003 美國馬里蘭大學(U. of Maryland at College Park) 化學工程學 碩士 1996 國立台灣大學 化學工程學 學士 1994 |
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| 專業技術 |
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| 生醫材料、組織工程、微米加工製程、微機電系統、生物磨潤學、奈米磨潤學、材料表面加工、薄膜技術、人工關節、骨科材料、高分子材料機械性質及破壞機制測試 | |||||||||||||||||||||||||||||||
| 研發介紹 |
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| ◎ 期刊論文 ： | |||||||||||||||||||||||||||||||
| "Influence of Biological Lubricant on the Morphology of UHMWPE Wear Particles Generated with Microfabricated Surface Textures",Materials Chemistry and Physics,280-288,2006/2/1(SCI) "Surface Texture Design to Generate Specific Sizes and Shapes of UHMWPE Wear Particles",Materialwissenschaft und Werkstofftech (Materials Science and Engineering Technology),976-988,2003/10/1(SCI) "Generation of Narrowly Distributed Ultra-high Molecular Weight Polyethylene Particles by Surface Texturing Techniques",Journal of Biomedical Materials Research, Part B: Applied Biomaterials,741-749,2003/10/1(SCI) "Receptor Activator of (RANK) and RANK LIGAND (RANKL) Expression in Response to Varying Morphology of UHMWPE Particles in a Murine Model of Inflammation",Biomaterials,4819-4826,2003/10/1(SCI) "Single wedge sliding tests to investigate the mechanism of UHMWPE particle generation with microfabricated surface textures",Polymer Testing,424-434,2006/5/1(SCI) "Generation of wear particles with specific size and shape for pre-clinical tests of orthopaedic implants",Journal of Orthopaedic Surgery, Taiwan,1-9,2006/3/1(ELSE2) "Effects of tribochemistry of synovial fluids on the performance of unicondylar knee arthroplasty: development of the testing model",Journal of Orthopaedic Surgery, Taiwan,10-15,2006/3/1(ELSE2) "Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivities",Journal of Biochemical and Biophysical Methods,175-187,2006/10/1(SCI) "Frictional characteristics of the tribological unfolding albumin for polyethylene and cartilage",Chemical Physics Letters,380-384,2006/12/1(SCI) "Structural analysis of human lysozyme using molecular dynamics simulations",Journal of Biomolecular Structure and Dynamics,229-238,2006/12/1(SCI) "The potential role of phagocytic capacity in osteolytic process induced by polyethylene wear particles",Journal of International Medical Research,???,2006/12/1(SCI) "Characteristic modeling of the wear particle formation process from a tribological testing of polyethylene with controlled surface asperities",Journal of Applied Polymer Science,587-594,2007/4/1(SCI) "軟骨組織工程之回顧與展望",中華創傷骨科雜誌,??,2006/12/1(ELSE2) "Association of polyethylene friction and thermal unfolding of interfacial albumin molecules",Applied Surface Science,6896-6904,2007/5/1(SCI) "Tribological process induced conformational transformation of protein may change the friction of articular cartilage",Materials Letters,3381-3384,2007/3/1(SCI) "Effects of hydroxyapatite dosage on mechanical and biological behaviors of polylactic acid composite materials",Materials Letters,3009-3013,2007/3/1(SCI) "Chemical chaperone and inhibitor discovery: potential treatments for protein conformational diseases",Perspectives in Medicinal Chemistry,39-48,2007/10/1(SCI) "Molecular Dynamics Simulations of Human Cystatin C and Its L68Q Varient to Investigate the Domain Swapping Mechanism",Journal of Biomolecular Structure & Dynamics,135-144,2007/10/1(SCI) "Molecular Dynamics Simulations of Human Cystatin C and Its L68Q Varient to Investigate the Domain Swapping Mechanism",Journal of Biomolecular Structure & Dynamics,135-144,2007/10/1(SCI) "Semiempirical molecular orbital studies of the acylation step in the lipase-catalyzed ester hydrolysis",Journal of the Chinese Chemical Society,835-842,2007/8/1(SCI) "Molecular Dynamics Simulations to Investigate the Domain Swapping Mechanism of Human Cystatin C",Biotechnology Progress,577-584,2007/10/1(SCI) "Sensitivity analysis of the semiempirical model for the growth of the indigenous Acidithiobacillus thiooxidans",Chemical Engineering Journal,105-112,2007/5/1(SCI) "Insights into the conformational changes of several human lysozyme variants associated with hereditary systemic amyloidosis",Biotechnology Progress,246-254,2007/2/1(SCI) "Accelerated wear testing with a microfabricated surface to evaluate the lubrication ability of biomolecules on polyethylene",Journal of Applied Polymer Science,2428-2437,2008/5/1(SCI) "Chondrocyte acting as phagocyte to internalize polyethylene wear particles and leads to the elevations of osteoarthritis associated NO and PGE2",Biochemical and Biophysical Research Communications,884-888,2008/5/1(SCI) "Conformational and adsorptive characteristics of albumin affect interfacial protein boundary lubrication: from experimental to molecular dynamics simulation approaches",Colloids and Surfaces B: Biointerfaces,171-177,2009/2/1(SCI) "Modulation of Gene Expression of Rabbit Chondrocytes by Dynamic Compression in Polyurethane Scaffolds with Collagen Gel Encapsulation",Journal of Biomaterials Applications,347-366,2009/1/1(SCI) "Molecular Dynamics Simulations to Investigate the Aggregation Behaviors of the A??(17-42) Oligomers",Journal of Biomolecular Structure & Dynamics,481-490,2009/2/1(SCI) "Recent Patents for nucleic acid sequencing and its applications",Current Topics in Biotechnology,21-33,2008/12/1(ELSE2) "Development and biological evaluation of C60 fulleropyrrolidine- thalidomide dyad as a new anti-inflammation agent",Bioorganic & Medicinal Chemistry,8619-8626,2008/9/1(SCI) "Chondrogenesis From Immortalized Human Mesenchymal Stem Cells: Comparison Between Collagen Gel and Pellet Culture Methods",Artificial Organs,561-566,2008/7/1(SCI) "Dip coating assisted polylactic acid deposition on steel surface: film thickness affected by drag force and gravity",Materials Letters,3739-3741,2008/8/1(SCI) "RING domains functioning as E3 ligases reveal distinct structural features: a molecular dynamics simulation study",Journal of Biomolecular Structure & Dynamics,65-74,2008/8/1(SCI) "Viscoelasticity and Wearability of Hyaluronate Solutions",Biochemical Engineering Journal,211-217,2008/6/1(SCI) "Artificial neural network to predict the growth of the indigenous Acidthiobacillus thiooxidans",Chemical Engineering Journal,231-237,2008/4/1(SCI) "Effect of electrostatic field on proliferation and cytokine secretion of macrophage cells",Biomedical Engineering,47-52,2008/2/1(SCI) "Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine",Bioorganic & Medicinal Chemistry Letters,99-103,2008/1/1(SCI) "Investigation of the friction induced conformational change of protein and wear of UHMWPE by a wear process with microfabricated surfaces",Materials Science and Engineering: C,1118-1123,2009/5/1(SCI) "Trends and Challenges of Cartilage Tissue Engineering",Biomedical Engineering-Applications, Basis and Communications,149-155,2009/6/1(SCI) "幹細胞於關節軟骨組織工程之新進展",台灣醫學,488-494,2009/9/1(ELSE1) "Quantitative analysis of osteoblast-like cells (MG63) morphology on nanogrooved substrata with various groove and ridge dimensions",Journal of Biomedical Materials Research: Part A,629-640,2009/9/1(SCI) "Dose-dependent effect of Lactobacillus GG on quantitative reduction of fecal rotavirus shedding in children",Journal of Tropical Pediatrics,297-301,2009/10/1(SCI) "以浸鍍法於生醫金屬表面製備多孔性聚乳酸薄層之研究",化工技術,84-95,2009/11/1(ELSE1) "Can low frequency electromagnetic field help cartilage tissue engineering",Journal of Biomedical Materials Research: Part A,843-851,2010/3/1(SCI) "A poly(prolylene furmate) – Calcium phosphate based angiogenic injectable bone cement for femoral head osteonecrosis",Biomaterials,4048-4055,2010/6/1(SCI) "Combined effects of polyethylene wear particle size and dosage on macrophage responses",Biomedical Engineering-Applications, Basis and Communications,279-291,2010/8/1(SCI) "“Inhibitory effects of Lactobacillus casei rhamnosus on Salmonella lipopolysaccharide-induced inflammation and epithelial barrier dysfunction in a co-culture model using Caco-2/peripheral blood mononuclear cells",Journal of Medical Microbiology,573-579,2010/2/1(SCI) "Nanoparticles prepared from the water extract of Gusuibu (Drynaria fortunei J. Sm.) protects osteoblasts against insults and promotes cell maturation",International Journal of Nanomedicine,1405-1413,2011/7/1(SCI) "Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model",Journal of Orthopaedic Research,1874-1880,2011/12/1(SCI) "建構綠色能源專業育成網絡之緣起、策略與成效",中小企業發展季刊,149-182,2011/6/1(ELSE1) "The effect of clockwise and counterclockwise twisting moments on abutment screw loosening",Clinical Oral Implant Research,1181-1186,2012/6/1(SCI) "A novel rotating electrochemically anodizing process to fabricate TiO2 surface nanostructures enhancing the bioactivity of osteoblastic cells",Journal of Biomedical Materials Research A,1687-1695,2012/7/1(SCI) "A strategy to enhance the biomedical articulation system by electrochemically texturing of metal surfaces",Biomedical Engineering,343-347,2012/8/1(SCI) "Lubricating characteristics of hyaluronic acid molecules on the albumin-mediated tribological processes",Biomedical Engineering,557-562,2012/11/1(SCI) "Cartilage fragements from osteoarthritic knee promote chondrogenesis of mesenchymal stem cells without exogenous growth factor induction",Journal of Orthopaedic Research,393-400,2012/3/1(SCI) "Fabrication of porous polylactic acid films assisted by dip-coating and template leaching techniques",Journal of Applied Polymer Science,2333-2339,2012/5/1(SCI) |
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| ◎ 研討會論文 | |||||||||||||||||||||||||||||||
| "MODELING OF THE GENERATION OF UHMWPE PARTICLES WITH MICROFABRICATED SURFACE TEXTURES",World Tribology Congress III,Washington, DC,2005/9/12 "EFFECTS OF BIOLOGICAL LUBRICATION ON THE MORPHOLOGY OF UHMWPE PARTICLES",World Tribology Congress III,Washington, DC,2005/9/12 "Effects Of Biological Lubricants On The Morphology Of UHMWPE Wear Particles Generated With Microfabricated Surfaces",25th Biotribology Symposium,Kobe,2005/6/3 "EFFECTS OF BIOFLUID LUBRICATION ON GENERATION OF UHMWPE PARTICLES WITH",51st Annual Meeting of the Orthopaedic Research Society,Washington, DC,2005/2/20 "A BIOPHYSICAL ANALYSIS OF PHAGOCYTOSIS OF WEAR PARTICLES FOR COMPARING THE FAILURE OF",51st Annual Meeting of the Orthopaedic Research Society,Washington, DC,2005/2/20 "生物流體的潤滑效應對利用微米加工表面產生的超高分子量聚乙烯顆粒之影響",中國化學工程學會年會,台南,2004/11/20 "生物潤滑液對超高分子量聚乙烯磨耗之影響",中華民國骨科醫學會年會,台北,2005/10/29 "發展測試模型以探討關節液摩擦化學反應對部份人工膝關節之影響",中華民國骨科醫學會年會,台北,2005/10/29 "生產特定形貌之磨耗顆粒以進行骨科植入物之臨床前測試",中華民國骨科醫學會年會,台北,2005/10/29 "Effects of biological lubrication on the wear performance of UHMWPE",First International Conference on Mechanics of Biomaterials & Tissues,Waikola, Hawaii,2005/12/11 "A Study of the Mechanism of UHMWPE Particle Generation with Microfabricated Surface Features: In situ Observation of Single-Tip Sliding Tests",7th World Biomaterials Congress,Sydney,2004/5/17 "Surface-Texture Design to Generate Narrowly Distributed UHMWPE Particles with Specific Sizes and Shapes",7th World Biomaterials Congress,Sydney,2004/5/17 "Analysis of UHMWPE Particle Shape Effects on Bioactivity from the Physical Viewpoint of Phagocytosis Process",7th World Biomaterials Congress,Sydney,2004/5/17 "利用微米製程加工之表面以控制超高分子量聚乙烯材料磨耗顆粒之大小與形狀",中華民國九十二年度醫學工程年會暨研討會,台北,2003/12/17 "以材料表面微米加工製程來控制人工關節磨耗顆粒及其所引發之生物反應之研究",中華民國九十三年度醫學工程年會暨研討會,台南,2004/12/17 "Size and Concentration of Wear Debris UHMWPE Particles Influence Local Inflammation and Bone Resorption",29th Society for Biomaterials Annual Meeting,Reno, Nevada,2003/4/30 "Analysis OF UHMWPE Particles Induced Biological Response: An Approach by Microfabrication of Particles and Biophysical Modeling of Phagocytosis",World Congress for Chinese Biomedical Engineers,台北,2002/12/1 "Micro-cutting Mechanism of Surface Texture Controlled UHMWPE Wear Particle Generation",28th Society for Biomaterials Annual Meeting,Tampa, FL,2002/4/24 "Tribological Process of Unicompartment Knee Arthroplasty (UKA) Induced Friction Change of Conterlateral Articular Cartilages",International Cartilage Repair Society Meeting,San Diego,2006/1/10 "Evaluation of biological lubrication by comparing UHMWPE wear particles in an accelerated wear testing process",52st Annual Meeting of Orthopaedic Research Society,Chicago,2006/3/1 "Conformational change of albumin induced by the wear process of UHMWPE",52st Annual Meeting of Orthopaedic Research Society,Chicago,2006/3/1 "Effects of tribochemistry of biological lubricant on the friction of cartilage: development of testing model to evaluate partial joint arthroplasty performance",52st Annual Meeting of Orthopaedic Research Society,Chicago,2006/3/1 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Applying dip coating process to improve bioactivity of implant surface",12th Symposium of Young Asian Biochemical Engineers' Community,Kaohsiung,2006/11/26 "Mixed solution of hyaluronic acid and phospholipids may enhance lubrication of artificial joint materials",6th Combined Meeting of the Orthopaedic Research Societies,,Honolulu,2007/10/20 "Relationship between friction of artificial joint materials and thermal unfolding of interfacial albumin",the 6th Combined Meeting of the Orthopaedic Research Societies,Honolulu,2007/10/20 "Preparation and animal study of PLA/TCP based biodegradable composite bone graft",the 6th Combined Meeting of the Orthopaedic Research Societies,Honolulu,2007/10/20 "Effect of protein conformational change on lubrication of cartilage in the partial joint arthroplasty",Annual Meeting of Orthopaedic Research Society,San Diego,2007/3/10 "Saturation level of phagocytic capacity affects macrophage secrected TNF-αinduced by UHMWPE wear particles",Annual Meeting of Orthopaedic Research Society,San Diego,2007/3/10 "A mechanistic study of protein boundary lubrication on joint implant surface",Annual Meeting of Orthopaedic Research Society,San Diego,2007/3/10 "UHMWPE particle induced osteolysis in a rat model",Annual Meeting of Orthopaedic Research Society,San Diego,2007/3/10 "磷脂質與蛋白質分子對人工關節材料摩擦行為之影響",中華民國九十六年度骨科醫學會,台北,2007/10/25 "Electrostatic field generated by altering current has a minor effect on MG-63 growth",中華民國九十六年度化學工程年會暨研討會,台北,2007/11/24 "Preparation of PLA/TCP composites scaffold by a new technology of salt-leaching method",中華民國九十六年度化學工程年會暨研討會,台北,2007/11/24 "以生物潤滑作用為基礎發展仿生潤滑技術-多成份生物及仿生潤滑分子之潤滑機制研究",中華民國九十六年度化學工程年會暨研討會,台北,2007/11/24 "關節潤滑液分子對人工關節表面之摩擦探討",中華民國九十六年度化學工程年會暨研討會,台北,2007/11/24 "建立快速檢測關節液成分之方法以探討其潤滑效用之研究",中華民國九十六年度化學工程年會暨研討會,台北,2007/11/24 "Effects of albumin conformation and adsorption on frictional behaviors: experimental and molecular dynamics simulation approaches",2nd International Conference and Advanced Tribology,Singapore,2008/12/3 "Effects of synovial biomolecules on tribological behaviors of arthroplastic surface",2nd International Conference and Advanced Tribology,Singapore,2008/12/3 "Dip-coating process assisted porous polylactic acid film formation on metal surface",2008 Annual Conference of Tissue Engineering and Regenerative Medicine International Society – Asian Pacific Region,Singapore,2008/12/2 "Dip coating assisted polylactic acid deposition on steel surface: Film thickness affected by drag force and gravity",The 13th International Conference on Biomedical Engineering,Singapore,2008/12/2 "Molecule dynamics simulation of albumin thermal unfolding and adsorption",8th World Biomaterials Congress,阿姆斯特丹,2008/5/27 |
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| ◎ 專書著作 | |||||||||||||||||||||||||||||||
| "Ultra-High Molecular Weight Polyethylene Wear Particle Effects on Bioactivity",NIST, 出版日期：2003/10/1, ISBN：NIST SP 1002 | |||||||||||||||||||||||||||||||
| 專利介紹 |
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專利行銷平台
