可授權專利


吳茱萸次鹼類似物及其應用
 RUTAECARPINE ANALOGS AND APPLICATIONS THEREOF


專利名稱 / Patent Title 吳茱萸次鹼類似物及其應用
RUTAECARPINE ANALOGS AND APPLICATIONS THEREOF
專利國家 / Country
   專利證書號 / Registration Number
美國 / US 10,526,333
專利權人 / Applicant 國立臺北科技大學 / National Taipei University of Technology
發明人 / Inventor 黃聲東/Sheng-Tung Huang

專利詳細說明
Patent Details

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技術摘要 / Abstract


本發明提供具有多種生物活性之RUT類似物。具體而言,該等生物活性包含抗發炎活性、血管舒張效應、遷移/侵襲阻抑活性、抵抗由於上皮與內皮之間之重塑所致損傷之能力、膠原沈積及心肌纖維化阻抑、Snail蛋白質抑制效應等,其可改善心臟、血管舒張及肺功能。本文所揭示之RUT類似物相較於RUT亦展現更低之細胞毒性。The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress, Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.


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